COCCISTOP S SOLUZIONE ORALE COCCIDIOSI PER POLLAME TACCHINI E CONIGLI
Active substances: Sulfaquinoxaline Oral solution for treatment of eimeria
Target species: hens, turkey hens and rabbits
Administration: orally Package: 50 ml, 100 ml, 1000 ml
COMPOSITION 1 ml of oral solution contains: Sulfaquinoxaline (as sodium)………………………. 200 mg Excipient q.s.ad………………………………………… 1 ml Excipient: Propylene glycol, Sodium hydroxide, Distilled water PHARMACOTHERAPEUTIC ACTION
Sulfaquinoxaline is a sulfonamide with outstanding anticoccidial (limits the activity of p-aminobenzoic acid in parasites cell) and antibacterial properties (especially against Gram-negative bacteria).
TARGET SPECIES Hens, turkey hens and rabbits.
COCCISTOP S – oral solution recommended for treatment of eimeria in: - chickens – caused by coccidiostats from Eimeridae family (Eimeria acervulina, E. necatrix, E. mitis, E. tenella, E. brunetti) - turkey chicks – caused by coccidiostats E. meleagridis, E. adenoides - rabbits – caused by coccidiostats E. perforans, E. intestinalis and E. magna COCCISTOP S – oral solution is also effective in the treatment of cholera and tiphosis in hens and turkey hens.
POSOLOGY, ROUTE AND METHOD OF ADMINISTRATION
Chickens and rabbits: 45 ml of Coccistop S per 22 liters of drinking water for 2 – 3 days, then pause for 3 days.
Then, 15 ml of Coccistop S per 11 liters of drinking water for two days followed by a break of two days and a last treatment with the same dilution (15 ml of Coccistop S per 11 liters drinking water).
Turkey chicks: 15 ml of Coccistop S per 11 liters of drinking water in 3 series for 2 consecutive days with 3 days pause.
Hens and turkey hens in cholera and tiphosis: 45 ml of Coccistop S per 22 liters of drinking water for 3 days. After 3 days break resume the treatment with 15 ml of Coccistop S per 11 liters of drinking water for 2 days.
CONTRAINDICATIONS, PRECAUTIONS AND ADVERSE REACTIONS
It is compulsory to associate the treatment with vitamin K3.
To avoid intoxication do not exceed the indicated concentrations. In warm conditions the solution is to be administrated only in the morning in drinking water, and during the rest of the day the water will be consumed in normal limits with no solution in it.
Generally, the product is well tolerated, though, hemorrhagic syndrome might appear manifested by anorexia, epistaxis, haemoptysis, mucous deviation and pallor.
The product can be used during gestation and lactic period. Do not use in hens and turkey hens producing eggs for human consumption. Sulphonamides potentiate the action provided by the hypoglycemic sulfonylureas (chlorpropamide, glibenclamid, tolbutamid) by moving from proteins.
The concomitant use of sulphonamides and isonuazid can cause hemolytic anemia. The action of penicillins, that are active only against multiplying bacteria, can be antagonized by sulphonamides.
Oxyphenbutazone and phenylbutazone increase the action of the bacteriostatic sulfonamides by moving from the proteins.
The probenecid increases the plasmatic level of sulphonamides, due to its influence over the excretion speed.
Methenamine do not associates with sulphonamides, since they split in aldehyde formation and it can form insoluble sulfonamides derivatives in the blood circuit. In birds, the overdose can cause toxic effects, such as: anemia, delay of the incubation period, bleedings in chest muscles and legs area.
Sulfaquinoxaline is incompatible with salinomycin and narasin.
WITHDRAWL TIME Meat and organs: 5 days
STORAGE CONDITIONS At a temperature below 25°C, away from direct sunlight and freezing.